Cannabis & CBD Doses

Cannabis, CBD, and the Time You Wait Between Doses

The length of time you wait between doses of cannabis and CBD can significantly impact your results.

Frequent cannabis users will attest to the buildup of a tolerance to the effects of cannabis over time. Tolerance, generally, refers to the body getting used to the cannabis, which can result in weaker effects.

As tolerance builds up, you are faced with a choice. Do you increase your dose to achieve the same benefits? Or do you determine an appropriate amount of time to wait between doses to achieve the benefits you seek, while keeping your ingestion and expenses to a minimum?

What is known about cannabis, CBD and tolerance?

There have been at least 22 cannabis tolerance studies performed over the last 50 years. 15 found some positive evidence of cannabis tolerance impacting the experience.

Several of these studies have also demonstrated that cannabis tolerance can indeed decrease for frequent users by taking a short break from use, often referred to as a “t-break.”

According to one study, while THC (one of the main active compounds in cannabis) can deplete certain cannabinoid receptors, they can recover over time and return to their previous levels. In their study, levels for a heavy cannabis user returned to normal in about 4 weeks.

The best length of time for a ”t-break” is a matter of great debate. It can depend on a range of factors including how often you use cannabis, your unique biochemistry, the products you’ve been using, and the dose. 

CBD products are said to not cause tolerance build-up due to how CBD does not bind to cannabinoid receptors as THC does. However, many frequent CBD users report to having “reverse tolerance,” where it takes lower dosing to achieve the desired effect.

What can you do to manage your tolerance?

Beyond taking a break, are there other things you can do?

Exercise is suspected to help prevent the build-up of tolerance to cannabis. Is your cannabis experience better if you exercise earlier that day?

Frequent users also will vary the products they are using because they suspect that certain aspects of their tolerance may be specific to a given product. Switching products, their thinking goes, can help.

Others suggest that using products blended with CBD, or using CBD-only products during a “t-break” may be a way to combat the buildup of tolerance,

How do you decide the best length of time for you to wait between doses?

Getting answers with Jointly

Jointly is Your Cannabis Companion – a smartphone app that answers your important questions by aggregating experiences from a community of users just like you. Jointly is safe, secure, private, unbiased, and easy to use. Jointly only includes legal and licensed products from legal and licensed brands.

Jointly can help you identify the best products for your goals, based on real experiences of other people, like you, with the same goals.

By submitting reports and ratings in Jointly, your own personal in-app Learning Center helps you understand how to improve your experience:

How do you find your optimal dose?
How much time should you wait between sessions?
How does ingestion method impact your experience?
How does time of day impact your experience?
Does it matter if you exercise before, during, or after cannabis use?
How does the amount of sleep you get the night before change things?
What about hydration?
How much food is in your stomach?
The quality of your diet?
Your environment?
The people you are with?

We hope you get the results you deserve. And, be sure to learn about the steps you can take to increase your odds of success.

And, if you have any feedback or ideas for improving Jointly, please let us know. We’re here to help, but also to learn.


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In no way is any of the information contained on this site or in the Jointly app intended to be a medical or prescriptive guide or a substitute for informed medical advice or care. If you believe or suspect that you have a medical problem, promptly contact your doctor or health care provider. You should never delay seeking or disregard advice from a medical professional based on something you have read here.

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